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  • Targets a compact 13 Mb region for SNVs, InDels (<50bp), and exon-CNV calling

  • This targeted coverage is sufficient to cover >99% of genes found in WES positive results

  • Unlike standard probes that struggle with difficult regions, eWES™ probes are optimized for capture efficiency in some complex areas

DMD capturing in eWES and other probe

Selective Capture

We utilize the eWES™ probe to capture the exons and splice sites of 4,773 definitively pathogenic genes recorded in databases and guidelines.

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eWES™ PCR-Free Library Preparation

The eWES™ library workflow completely removes the amplification step, ensuring superior data fidelity.

  • PCR-free approach lowers the error rate and eliminates bias

  • Uniform coverage delivers consistent depth, minimizing data waste

  • Reduces hands-on time without sacrificing quality

  • Utilizing 1 single-plex capture (1 sample per reaction) ensures data consistency across every sample batch

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WESisi System: From Sample to Report

The WES Integrated System of Interpretation (WESisi) is a comprehensive management platform covering the entire workflow—from sample registration to the final clinical report. Available as a secure Cloud solution or a Local Server installation.​

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  • One system for both WES and custom exome panels

  • Compatible with external sequencing data and various capture probes

  • Equipped with industry-standard tools (e.g. GATK, CNVkit, XHMM) alongside our proprietary algorithms

Explore

End-to-End Technology Transfer

Xcelom Limited and Berry Genomics provide an end-to-end turnkey solution for labs wishing to conduct this test in-house. We specialize in bioinformatics and analysis support, helping laboratories master the complexities of variant annotation and interpretation. Our solutions streamline the workflow and assist with ACMG classification by automatically integrating relevant public databases.​

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  • Laboratory Setup: Full consultation

  • Workflow Integration: SOPs, IVD/RUO reagents, and staff training

  • Bioinformatics: Complete software suite for sample management and automated report generation

Platform

illumina or Salus SBS sequencing system

Sample Type

gDNA from blood, CVS, amniotic fluid, cord blood/tissue, product of conception, etc.

Automation 

Yes

Coverage

SNVs, InDels (<50bp), and exon-CNVs in exons and splice sites of 4,773 genes

Resources

Brochure

Short-Read Sequencing 

Clinical Exome Sequencing (CES) Panel

Technology Transfer: 
Standardize with a focused, economical workflow

The Strategy: Focusing on Clinically Relevant Genes

Unlike comprehensive Whole Exome Sequencing (WES), Clinical Exome Sequencing (CES) targets a curated set of genes strongly associated with known phenotypes. By narrowing the capture range, laboratories can optimize sequencing costs while maintaining high diagnostic yields for carrier screening and disease diagnosis.

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One Workflow, Multiple Panels

We have designed a standardized, economical CES workflow that targets only the genes with clear clinical evidence. Whether your lab offers neurogenetic panels, cardiovascular panels, or others, you use the same laboratory workflow and reagents. This allows you to seamlessly expand your service menu while maintaining operational consistency.

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References:

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