Xcelom Limited (Global)
Long-read sequencing
HemoSure™
Blood Group/ RBC/ HPA Genotyping
Beyond Serology: High-Resolution typing for Safer Transfusion
HemoSure™ RBC Genotyping Panel
Conventional serological assays frequently fail to identify weak phenotypes, subtypes, and rare types. This makes them highly prone to misinterpretation, posing significant risks to blood transfusion safety. Blood group genotyping is indicated in a wide range of scenarios where serological typing alone cannot provide a definitive answer. These include, but are not limited to:
-
ABO Subtypes
-
Hematological Disorders Requiring Long-Term Transfusion
-
Malignancies
-
Drug-Induced Interference
-
Congenital or Post-Transplant Chimerism
-
Autoimmune Diseases
-
Leukemia
HemoSure™ delivers high-resolution genotyping across multiple blood group systems, accurately resolving highly homologous genes and complex variants that are commonly mismapped by NGS. From challenging discrepancies such as cis-AB and B(A) to the identification of null alleles, HemoSure™ provides definitive, unambiguous results, where conventional methods fall short.
HemoSure™ Human Platelet Antigen (HPA) Genotyping
Mismatched platelet transfusions can lead to serious adverse events including platelet transfusion refractoriness (PTR) and alloimmune thrombocytopenia. Beyond transfusion, HPA polymorphisms are closely linked to disease susceptibility, platelet-pathogen interactions, platelet-malignant cell interactions, and cardiovascular disease risk.
HemoSure™ HPA genotyping delivers comprehensive coverage across all HPA-1 to HPA-35 loci. Combined with AltruType™ HLA genotyping and HemoSure™ RBC genotyping, this creates a complete genotyping ecosystem for transplant medicine, bone marrow registries, and blood banking.
HemoSure™ Panel
Panel
Gene
Blood Group
Antigen
ABO Typing
ABO, FUT1, and FUT2
ABO and Hh
A, B, and H
Rh Typing
RHD, RHCE, and RHAG
RHD weak D, partial D, and DEL
D, C, c, E, e, Duclos, Olᵃ ...
RBC Typing (Panel 1)
ABO, RHD, RHCE, GYPA, GYPB, SLC14A1, and ACKR1
ABO, Rh, MNS, Kidd, and Duffy
A, B, D, C, c, E, e, M, N, S, s, Mur, Miª, Jkª, Jkᵇ, Fyª, Fyᵇ ...
RBC Typing (Panel 2)
ABO, RHD, RHCE, GYPA, GYPB, SLC14A1, ACKR1, A4GALT, B3GALNT1, KEL, FUT2, FUT3, and SLC4A1
ABO, Rh, MNS, Kidd, Duffy, P1PK, Kell, Lewis, and Diego
A, B, D, C, C, E, e, M, N, S, s, Mur, Miª, Jkª, Jkb, Fyª, Fyᵇ, P1, Pk, K, k, Kрª, Kpᵇ, Leª, Leb, Diª, Diᵇ, Wrª ...
RBC Typing (Extended)
FUT1, FUT2, B3GALNT1, ABCG2, KLF1, ABCB6, SMIM1, BCAM, ART4, CR1, C4A, C4B, XG, CD99, XK, ICAM4, and CD36
H, GLOB, JR, LAN, Vel, Lutheran, Dombrock, Knops, Chido/Rodgers, XG, Kx, LW, and CD36
H, P, Jr, Lan, Vel, Luª, Luᵇ, Doª, Doᵇ, Hy, Joª, Gyª, Knª, Knᵇ, McCª, Ch1, Ch2, Xgª, CD99, Kx, LWª, LWªᵇ, LWᵇ, CD36.1 ...
HPA Typing
CD109, ITGA2B, GP1BB, GP9, ITGA2, ITGB3, and GP1BA
HPA-1a/b, HPA-2a/b, HPA-3a/b......HPA-34a/b, HPA-35a/b
End-to-End Technology Transfer
Xcelom Limited and Haorui Genomics provide a comprehensive end-to-end turnkey solution for conducting HLA typing tests within your facility.
From Sample to Report:
-
Laboratory setup and consultation
-
End-to-end Workflow: SOPs, reagent, and training
-
Analysis Software: From sample management to report generation
_edited.png)
Platform
PacBio Sequel IIe, Vega and Revio system
Sample Type
gDNA from blood
Test per Batch
1 - 192 tests per SMRT cell
Operation Time
~ 40.5 hours (Hand on time: ~85 minutes)
Automation
Supported
Please note that all working times are approximate and may vary depending on laboratory practices, hardware, and sample number.
Further Scope Expansion - AltruType™ HLA Series
In addition to our HemoSure™ panels, we offer expanded AltruType™ HLA typing solution. These solutions help service laboratories to broaden their offerings using the similar workflow, same sequencing run and analysis platform.
Different Assays. Separate Reactions. One Universal Protocol.
